更新日:2010年7月22日
 
1. 脳・神経・精神2. 眼科│3. 歯科│4. 頭頸部5. 呼吸器6. 乳腺7. 循環器│8. 肝胆膵│9. 消化管│
10. 泌尿・生殖器│11. 骨・関節│12. 皮膚│13. 内分泌・代謝│14. 血液│15. 免疫・アレルギ -│16. 小児│17. その他
 
1. 脳・神経・精神
UHA SCI 04-01
急性期脊髄損傷に対する培養自家骨髄間質細胞移植による脊髄再生治療の検討 第Ⅰ-Ⅱ相試験
 
Saito F, Nakatani T, Iwase M, Maeda Y, Hirakawa A, Murao Y, Suzuki Y, Onodera R, Fukushima M, Ide C.
Spinal cord injury treatment with intrathecal autologous bone marrow stromal cell transplantaion: the first clinical trial case report.
The Journal of Trauma. 2008; 64: 53-59.
 
2. 眼科
UHA AMD 04-01
加齢黄斑変性の診断・治療・予後の実態調査
 
Hirami Y, Mandai M, Takahashi M, Teramukai S, Tada H, Yoshimura N.

Association of clinicalcharacteristics with disease subtypes, initial visual acuity, and visual prognosis in neovascular age-related macular degeneration.

Jpn J Ophthalmol. 2009 Jul;53(4):396-407.
 
4. 頭頸部
BRI HN 05-01
頭頸部扁平上皮癌根治治療後のTS-1補助化学療法の検討 -多施設無作為化比較試験-
 
Katori H, Tsukuda M, Taguchi T.
Concurrent chemoradiotherapy with carboplatin and uracil-f tegafur(UFT) for patients with poor performance status with locally advanced squamous cell carcinoma of the head and neck(SCCHN).
Acta Oto-Laryngologica. 2007; 8: 1-6.
Tsukuda M, Kida A, Fujii M, Kono N, Yoshihara T, Hasegawa Y, Sugita M. Chemotherapy Study Group of Head and Neck Cancer.
Randomized scheduling feasibility study of S-1 for adjuvant chemotherapy in advanced head and neck cancer.
British Journal of Cancer. 2005; 93: 884-889.
 
UHA HN 03-01, 04-01 & 04-02
上咽頭癌に対する化学療法(CDDP, 5FU)と放射線治療との交替療法第Ⅱ相試験
T2下咽頭癌に対する5FU, Nedaplatin(NDP)と放射線治療の交替療法 第II相試験
高齢者喉頭癌・下咽頭癌に対するweekly Docetaxelと放射線治療の併用療法に関する第Ⅱ相臨床試験

 
Fuwa N., Ariji Y, Wakisaka M, Matsumoto A, Kodaira T, Furutani K, Tachibana H, Ichimiya Y, Tomita N, Hidano M, Daimon T.
Relationship between the growth pattern of nasopharyngeal cancer and the cervical lymph nodes based on MRI findings: Can the cervical radiation field be reduced in patients with nasopharyngeal cancer?
The British Journal of Radiology. 2006; 79: 725-9.
 
 
5. 呼吸器
UHA CAD 05-01
血液透析患者の心疾患診療における123I-BMIPP SPECTの有用性検討のための調査研究
 
Hasebe N, Moroi M, Nishimura M, Hara K, Hase H, Hashimoto A, Kumita S, Haze K, Momose M, Nagai Y, Sugimoto T, Kusano E, Akiba T, Nakata T, Nishimura T, Tamaki N, Kikuchi K.
Prognostic Study of Cardiac Events in Japanese High Risk Hemodialysis Patients Using 123I-BMIPP-SPECT:B-SAFE Study Design
therapeutic Apheresis and Dialysis 12(6):526-530.
 
JMTO LC 00-04
進行非小細胞肺癌に対するビノレルビン+ゲムシタビン+ドセタキセルの3 剤化学療法とパクリタキセル+カルボプラチンの2剤化学療法との臨床第Ⅲ相試験(JMTO LC00-03)における治療感受性や予後に関わる遺伝子異常の研究
 
Isa S, Kawaguchi T, Teramukai S, Minato K, Ohsaki Y, Shibata K, Yonei T, Hayashibara K, Fukushima M, Kawahara M, Furuse K, Mack PC.
Serum osteopontin levels are highly prognostic for survival in advanced non-small cell lung cancer: results from JMTO LC 0004.
J Thorac Oncol. 2009 Sep;4(9):1104-10.
 
JMTO LC 00-03
進行非小細胞肺癌に対するビノレルビン+ゲムシタビン+ドセタキセルの3剤化学療法とパクリタキセル+カルボプラチンの2剤化学療法との臨床第Ⅲ相比較試験
 
Kishida Y, Kawahara M, Teramukai S, Kubota K, Komuta K, Minato K, Mio T, Fujita Y, Yonei T, Nakano K, Tsuboi M, Shibata K, Atagi S, Kawaguchi T, Furuse K, Fukushima M.
Chemotherapy-induced neutropenia as a prognostic factor in advanced non-small-cell lung cancer: results from Japan Multinational Trial Organization LC00-03.
Br J Cancer. 2009 Nov 3;101(9):1537-42.
Gandara DR, Kawaguchi T, Crowley J, Moon J, Furuse K, Kawahara M, Teramukai S, Ohe Y, Kubota K, Williamson SK, Gautschi O, Lenz HJ, McLeod HL, Lara PN Jr, Coltman CA Jr, Fukuoka M, Saijo N, Fukushima M, Mack PC.
Japanese-US common-arm analysis of paclitaxel plus carboplatin in advanced non-small-cell lung cancer: a model for assessing population-related pharmacogenomics.
J Clin Oncol. 2009 Jul 20;27(21):3540-6.
Teramukai S, Kitano T, Kishida Y, Kawahara M, Kubota K, Komuta K, Minato K, Mio T, Fujita Y, Yonei T, Nakano K, Tsuboi M, Shibata K, Furuse K, Fukushima M.
Pretreatment neutrophil count as an independent prognostic factor in advanced non-small-cell lung cancer: an analysis of Japan Multinational Trial Organisation LC00-03.
Eur J Cancer. 2009 Jul; 45(11):1950-8.
Kubota K, Kawahara M, Ogawara M, Nishiwaki Y, Komuta K,Minato K, Fujita Y, Teramukai S, Fukushima M, Furuse K; on behalf of the Japan Multi-National Trial Organisation.
Vinorelbine plus gemcitabine followed by docetaxel versus carboplatin plus paclitaxel in patients with advanced non-small-cell lung cancer: a randomised, open-label, phase III study.
The Lancet Oncology. 2008; 9: 1135-1142.
 
6. 乳腺
UHA BC 03-01
アントラサイクリン、タキサン系抗癌薬に不応性の転移性乳癌に対するトラスツズマブとカペシタビン併用療法の有効性および安全性の評価 第II相臨床試験
 
Ishida T., Kiba T., Takeda M., Matsuyama K., Teramukai S., Ishiwata R., Masuda N., Takatsuka Y., Noguchi S., Ishioka C., Fukushima M., Ohuchi N.
Phase II study of capecitabine and trastuzumab combination chemotherapy in patients with HER2 overexpressing metastatic breast cancers resistant to both anthracyclines and taxanes.
Cancer Chemotherapy and Pharmacology. 2009; 64: 361?369.
 
7. 循環器
BRI ASO 03-01
慢性重症下肢虚血(慢性閉塞性動脈硬化症・バージャー病)患者を対象とした、自家末梢血血管内皮前駆細胞(CD34陽性細胞)移植による血管再生治療に関する第Ⅰ-Ⅱ相試験
 
Kawamoto A, Katayama M, Handa N, Kinoshita M, Takano H, Horii M, Sadamoto K, Yokoyama A, Yamanaka T, Onodera R, Kuroda A, Baba R, Kaneko Y, Tsukie T, Kurimoto Y, Okada Y, Kihara Y, Morioka S, Fukushima M, Asahara T.
Intramuscular transplantation of G-CSF-mobilized CD34(+) cells in patients with critical limb ischemia: a phase I/IIa, multicenter, single-blinded, dose-escalation clinical trial.
Stem Cells. 2009 Nov;27(11):2857-64.
 
TRIPAD0703
G-CSF動員自家末梢血単核球細胞移植の臨床効果と安全性に関するレトロスペクティブ調査
 
Horie T, Onodera R, Akamastu M, Ichikawa Y, Hoshino J, Kaneko E, Iwashita C, Ishida A, Tsukamoto T, Teramukai S, Fukushima M, Kawamura A; for Japan Study Group of Peripheral Vascular Regeneration Cell Therapy (JPRCT).
Long-term clinical outcomes for patients with lower limb ischemia implanted with G-CSF-mobilized autologous peripheral blood mononuclear cells.
Atherosclerosis. 2010 Feb;208(2):461-6.
 
HEART 03-01
日本における経皮的冠動脈インターベンション(PCI)および冠動脈バイパス手術(CABG)の レジストリー Coronary Revascularization Demonstrating Outcome Study in Kyoto (CREDO-Kyoto)
 
Furukawa Y, Ehara N, Taniguchi R, Haruna Y, Ozasa N, Saito N, Doi T, Hoshino K, Tamura T, Shizuta S, Abe M, Toma M, Morimoto T, Teramukai S, Fukushima M, Kita T, Kimura T; CREDO-Kyoto Investigators.
Coronary risk factor profile and prognostic factors for young Japanese patients undergoing coronary revascularization.
Circ J. 2009 Aug;73(8):1459-65.
Nishiyama K, Horiguchi M, Shizuta S, Doi T, Ehara N, Tanuguchi R, Haruna Y, Nakagawa Y, Furukawa Y, Fukushima M, Kita T, Kimura T.
Temporal pattern of strokes after on-pump and off-pump coronary artery bypass graft surgery.
Ann Thorac Surg. 2009 Jun;87(6):1839-44.
Kimura T., Morimoto T., Furukawa Y., Nakagawa Y., Shizuta S., Ehara N., Taniguchi R., Doi T., Nishiyama K., Ozasa N.,Saito N., Hoshino K., Mitsuoka H., Abe M., Toma M., Tamura T., Haruna Y., Imai Y., Teramukai S., Fukushima M., Kita T.
Long-term outcomes of coronary-artery bypass graft surgery versus percutaneous coronary intervention for multivessel coronary artery disease in the bare-metal stent era.
Circulation. 2008; 118: S199-S209.
Furukawa Y., Taniguchi R., Ehara N., Ozasa N., Haruna Y., Saito N., Doi T., Hoshino K., Shizuta S., Morimoto T., Imai Y., Teramukai S., Fukushima M., Kita T., Kimura T.
Better survival with statin administration after revascularization therapy in Japanese patients with coronary artery disease: perspectives from CREDO-Kyoto registry.
Circulation Journal. 2008; 72: 1937-1945.
 
UHA ASO 05-01
 
Matoba S, Tatsumi T, Murohara T, Imaizumi T, Katsuta Y, Ito M, Saito Y, Uemura S, Suzuki H, Fukumoto S, Yamamoto Y, Onodera R, Teramukai S, Fukushima M, Matsubara H. TACT Follow-up Study Investigators.
Long-Term clinical outcome after intramuscular implantation of bone marrow mononuclear cells (TACT Trial) in patients with chronic limb ischemia.
American Heart Journal. 2008; 156: 1010-1018.
 

13. 内分泌・代謝

STAT 04-02
ヘテロ接合体性家族性コレステロール血症患者におけるプロブコール特別調査
 
Yamashita S, Hbujo H, Arai H, Harada-Shiba M, Matsui S, Fukushima M, Saito Y, Kita T, Matsuzawa Y.
Long-term probucol treatment prevents secondary cardiovascular events: a cohort study of patients with heterozygous familial hypercholesterolemia in Japan.
J Atheroscler Thromb. 2008 2008 Dec;15(6):292-303.
 
16. 小児
UHA PED 03-01 & UHA PED 03-02
横紋筋肉腫低リスクA群患者に対する短期間VAC1.2療法の有効性および安全性の評価
第Ⅱ相臨床試験
横紋筋肉腫低リスクB群患者に対するVAC2.2/VA療法の有効性および安全性の評価
第Ⅱ相臨床試験
 
Hosoi H., Teramukai S., Matsumoto Y., Tsuchiya K., Iehara T., Hara J., Mitsui T., Kaneko M., Hatae Y., Hayashi Y., Mabuchi O., Adachi N., Morikawa Y., Nishimura S., Kumagai M., Takamatsu H., Sawada T., Sugimoto T.
A review of 331 rhabdomyosarcoma cases in patients treated between 1991 and 2002 in Japan.
International Journal of Clinical Oncology. 2007; 12: 137-145.
 
17. その他
STAT 03-02
放射線感受性遺伝子研究プロジェクト
 
Iwakawa M, Noda S, Yamada S, Yamamoto N, Miyazawa Y, Yamazaki H, Kawakami Y, Matsui Y, Tsujii H, Mizoe J, Oda E, Fukunaga Y, Imai T.
Analysis of Non-Genetic Risk Factors for Adverse Skin Reactions to Radiotherapy among 284 Breast Cancer Patients.
Breast Cancer. 2006; 13(3): 300-7.
 
STAT 03-03
「PETスクリーニング」による癌死亡率低下の検証
 
Nishizawa S, Kojima S, Teramukai S, Inubushi M, Kodama H, Maeda Y, Okada H, Zhou B, Nagai Y, Fukushima M.
Prospective evaluation of whole-body cancer screening with multiple modalities including 18F-fluorodeoxyglucose positron emission tomography in a healthy population: a preliminary report.
Journal of Clinical Oncology. 2009; 27(11): 1767-1773.
 
STAT 04-01
 
Yamanaka T, Matsumoto S, Teramukai S, Ishiwata R, Nagai Y, Fukushima M.
Safety evaluation of oral fluoropyrimidine S-1 for short- and long-term delivery in advanced gastric cancer: analysis of 3,758 patients.
Cancer Chemotherapy and Pharmacology. 2008; 61: 335-343.
Yamanaka T, Matsumoto S, Teramukai S, Ishiwata R, Nagai Y, Fukushima M.
Predictive value of chemotherapy-induced neutropenia for the efficacy of oral fluoropyrimidine S-1 in advanced gastric carcinoma.
British Journal of Cancer. 2007; 97: 37-42.
Yamanaka T, Matsumoto S, Teramukai S, Ishiwata R, Nagai Y, Fukushima M.
Analysis of risk factors for severe adverse effects of oral 5-fluorouracil S-1 in patients with advanced gastric cancer.
Gastric Cancer. 2007; 10: 129-134.
Yamanaka T, Matsumoto S, Teramukai S, Ishiwata R, Nagai Y, Fukushima M.
The baseline ratio of neutrophils to lymphocytes is associated with patient prognosis in advanced gastric cancer.
Oncology. 2007; 73: 215-220.
 
STAT 04-02
ヘテロ接合体性家族性コレステロール血症患者におけるプロブコール特別調査
 
Yamashita S, Hbujo H, Arai H, Harada-Shiba M, Matsui S, Fukushima M, Saito Y, Kita T, Matsuzawa Y.
Long-term probucol treatment prevents secondary cardiovascular events: a cohort study of patients with heterozygous familial hypercholesterolemia in Japan.
J Atheroscler Thromb. 2008 2008 Dec;15(6):292-303.
 
 
 
 
 
│1. 脳・神経・精神│2. 眼科│3. 歯科│4. 頭頸部5. 呼吸器6. 乳腺7. 循環器│8. 肝胆膵│9. 消化管│
10. 泌尿・生殖器│11. 骨・関節│12. 皮膚│13. 内分泌・代謝│14. 血液│15. 免疫・アレルギ -│16. 小児17. その他
 
4. 頭頸部
BRI HN 05-01
頭頸部扁平上皮癌根治治療後のTS-1補助化学療法の検討 -多施設無作為化比較試験-

Tsukuda M. Recent chemotherapy for advanced head and neck cancer in our institutes. 3rd World congress of International Federation of Head and Neck Oncologic Society. June 28, 2006 Prague

Tsukuda M. Recent chemotherapy for head and neckcancer in Japan. Franco-Japanese Meeting on Cancer Chemotherapy in Sapporo. Sapporo, Sept. 17, 2005

Tsukuda M. Recent treatment modality for locoregionally advanced head and neck carcinoma. Symposium. The 8th Taiwan-Japan conference in otolaryngology, head and neck surgery. Dec. 18 Taipei, Taiwan 2005
 
5. 呼吸器
JMTO LC 00-03
進行非小細胞肺癌に対するビノレルビン+ゲムシタビン+ドセタキセルの3剤化学療法とパクリタキセル+カルボプラチンの2剤化学療法との臨床第Ⅲ相比較試験
 
S. Teramukai, T. Nishimura, M. Nakagawa, M. Kawahara, K. Kubota, K. Furuse, M. Fukushima, JMTO LC00-03 Study Group
Predictors and impacts of second-line chemotherapy on survival after progression in patients with advanced non-small cell lung cancer (NSCLC).
2007 ASCO Annual Meeting, Chicago, Illinois, June 1-5
2007.J Clin Oncol 25: 2007 (June 20 supple; abstr 7675)
M. Kawahara, M. Ogawara, Y. Nishiwaki, K. Kubota, K. Komuta, K. Minato, Y. Fujita, H. Origasa, M. Fukushima, K. Furuse, JMTO LC00-03.
Phase III randomized study of vinorelbine (V), gemcitabine (G) followed by docetaxel (D) (VGD) versus paclitaxel (P) and carboplatin (C) (PC) in patients (pts) with advanced non-small cell lung cancer (NSCLC) (Japan Multinational Trial Organization LC00-03).
2006 ASCO Annual Meeting, Atlanta, Georgia, June 2-6, 2006.
J Clin Oncol 24: 2006 (June 20 supple; abstr 7013)
 
6. 乳腺
UHA BC 03-01
アントラサイクリン、タキサン系抗癌薬に不応性の転移性乳癌に対するトラスツズマブとカペシタビン併用療法の有効性および安全性の評価 第II相臨床試験

T. Ishida, T. Kiba, M. Takeda, K. Matsuyama, S. Teramukai, N. Masuda, Y. Takatsuka, S. Noguchi, M. Fukushima, N. Ohuchi.
Phase II study of capecitabine and trastuzumab combination chemotherapy in patients with HER2-overexpressing metastatic breast cancers after failure of both anthracyclines and taxanes.

2008 ASCO Annual Meeting. May 20,2008.
J Clin Oncol 26: 2008 (May 20 suppl; abstr 1117)
 
7. 循環器
BRI ASO 03-01
慢性重症下肢虚血(慢性閉塞性動脈硬化症・バージャー病)患者を対象とした、自家末梢血血管内皮前駆細胞(CD34陽性細胞)移植による血管再生治療に関する第Ⅰ-Ⅱ相試験

Kawamoto A, Katayama M, Handa N, Kinoshita M, Kihara Y, Asahara T.
A phase I/ II, single-blind, dose-escalation, clinical trial of autologous CD34+ cell transplantation in intractable patients with chronic critical limb ischemia.
European Society of Cardiology Congress 2007. September 4th, 2007. Vienna, Austria.

Kawamoto A, Katayama M, Handa N, Kinoshita M, Baba R, Takano H, Kihara Y, Morioka S, Fukushima M, Asahara T.
Safety and efficacy is sustained up to one year after transplantation of autologous CD34+ cells in no-option patients with chronic critical limb ischemia.

Scientific Sessions 2006, American Heart Association. November 13, 2006. Chicago, IL. Circulation, 2006,114(18)Supplement II: II-446.

Kawamoto A, Katayama M, Handa N, Kinoshita M, Takano H, Baba R, Fukushima M, Kihara Y, Morioka S, Asahara T.
Transplantation of autologous endothelial progenitor cells is safe, feasible and effective for vascular regeneration in no-option patients with critical limb ischemia.

55th Annual Scientific Session, American College of Cardiology. March 12, 2006. Atlanta, GA. J. Am. Coll. Cardiol. 2006;47(4) (suppl A): 304A.

Kawamoto A, Katayama M, Handa N, Kinoshita M, Takano H, Baba R, Kuroda A, Fukushima M, Kihara Y, Morioka S, Asahara T.
Transplantation of autologous endothelial progenitor cells is safe, feasible and effective for vascular regeneration in no-option patients with chronic critical limb ischemia.
Scientific Sessions 2005, American Heart Association. November 15, 2005.
Dallas, TX, USA. Circulation. 2005; Suppl II 112(17):II-619.
 
10. 泌尿・生殖器
BRI GU 04-01
日本における前立腺癌に対するヨウ素125密封小線源永久挿入療法に関する前向きコホート研究 (J-POPS)

S. Saito, T. Kiba, M. Aoki, K. Ito, H. Koga, T. Yamashita, S. Kitagawa, T. Daimon, T. Dokiya, H. Yamanaka Japanese prostate cancer outcome study of permanent I-125 seed implantation (J-POPS study): Interim results of a prospective cohort study assessing efficacy, safety and QOL.
2008 ASCO Annual Meeting. May 20, 2008.
J Clin Oncol 26: 2008 (May 20 suppl; abstr 16137)
 
17. その他
STAT 03-03
「PETスクリーニング」による癌死亡率低下の検証

S. Nishizawa, M. Inubushi, H. Okada, F. Ozawa, S. Kojima, S. Teramukai, M. Fukushima.
Cancer screening trial to evaluate the efficacy of FDG-PET in healthy subjects: 2-year results of the Hamamatsu Medical Imaging Center study.
2006 ASCO Annual Meeting, Atlanta, Georgia, June 2-6, 2006.
J Clin Oncol 24: 2006 (June 20 supple; abstr 1025)
S. Kojima, M. Inubushi, F. Ozawa, H. Okada, M. Tanaka, Y. Fukunaga, E. Oda, S. Teramukai, M. Fukushima, S. Nishizawa.
Cancer screening trial using whole-body 18F-FDG-PET scanin healthy subjects
- Hamamatsu Medical Imaging Center study.
2005 ASCO Annual Meeting, Orlando, Florida, May 13-17, 2005.
J Clin Oncol 23: 2005 (June 1 supple; abstr 1022)
.
 
 
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